The 10-kilometre seafront test is the traditional race closer, with Wout Poels in the thick of the fight for a strong finish in sixth place.
The Dutchman finished amid the bunch in Jesi, retaining his position, 2:39 back on leader Adam Yates (Mitchelton-Scott).
Ahead of the final day in San Benedetto del Tronto, Team Sky Sport Director Matteo Tosatto gave us the lowdown on the decisive test, which could be a good stage for Filippo Ganna.
The Italian told TeamSky.com: “The TT in Tirreno-Adriatico has been the same for a few years now. The parcours is very straightforward, not technical, and it’s possible that Filippo could go very well. The distance is perfect for him, at only 10km.
“Castro could go well too - for many years he has had a good result at San Benedetto del Tronto. Wout needs to take back 15 seconds on (Julian) Alaphilippe to make the top five. It will be very difficult, at only 10km. But it should be a good day for Castro and Filippo, and we keep our fingers crossed for Wout.”